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  5. G-CSF ameliorates neuronal apoptosis through GSK-3β inhibition following HI in rats

G-CSF ameliorates neuronal apoptosis through GSK-3β inhibition following HI in rats

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：szhg5583
【摘 要】
：
Our objective is to investigate if Granulocyte-colony stimulating factor (G-CSF) administration will attenuate neuronal apoptosis after neonatal hypoxia-ischemia (HI) via glycogen synthase kinase-3β (
【作 者】
：
Li Li Damon Klebe Desislava Doycheva Devin W. Bride Paul K Jerry Flores Changman Zhou John H.Zhang Jiping Tang 
【机 构】
：
Department of Anatomy and Histology, Peking University Health Science Center, Beijing, China
【出 处】
：
The 18th Congress of the International Federation of Associa
【发表日期】
：
2014年8期
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Our objective is to investigate if Granulocyte-colony stimulating factor (G-CSF) administration will attenuate neuronal apoptosis after neonatal hypoxia-ischemia (HI) via glycogen synthase kinase-3β (GSK-3β) inhibition.157 pl0 pups were subjected to HI or sham surgery.HI animals received vehicle control siRNA, GSK-3β siRNA, G-CSF, G-CSF combined with G-CSFR siRNA, Wortmannin or DMSO.
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