【摘 要】
：
目的 探讨胃肠道间质瘤患者的临床特点及其预后的危险因素.方法 回顾性分析生物芯片上海国家工程研究中心所属生物样本库(生物银行)所存储的2004年8月至2014年4月均接受了手术治疗的293例胃肠道间质瘤患者的临床表现,并对其中135例患者的生存状态进行了系统性分析.应用KaplanMeier法和log-rank检验对胃肠道间质瘤的生存期进行分析.结果 在293例接受了肝癌切除术的患者中,男170例
【机 构】
：
200065 同济大学医学院附属同济医院消化科消化疾病研究所 生物芯片上海国家工程研究中心上海分子
【出 处】
：
The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
论文部分内容阅读
目的 探讨胃肠道间质瘤患者的临床特点及其预后的危险因素.方法 回顾性分析生物芯片上海国家工程研究中心所属生物样本库(生物银行)所存储的2004年8月至2014年4月均接受了手术治疗的293例胃肠道间质瘤患者的临床表现,并对其中135例患者的生存状态进行了系统性分析.应用KaplanMeier法和log-rank检验对胃肠道间质瘤的生存期进行分析.结果 在293例接受了肝癌切除术的患者中,男170例(58.2％),女122例(41.8％),余不详,年龄＞60岁119例(40.6％)；229例患者术后测量了肿瘤的最大直径,其中55例(24.0％)的最大直径≤5 cm,135例(59.0％)的最大直径＞5 cm且≤10 cm,39例(17.0％)的最大直径＞10 cm.120例患者具有其淋巴结转移情况的记录,其中发生淋巴结转移的患者为5例(4.2％).筛选出88例各项临床特征数据齐全的患者进行生存期分析,患者的平均生存时间为72.9个月,第1、2、3、4、5年的累计生存率分别为0.952、0.923、0.869、0.814和0.780.以肿瘤病灶的直径5 cm为标准将患者分为两组,对比其进行生存曲线发现两组生存期的差异具有统计学意义(P=0.046).结论 临床确诊的胃肠道间质瘤肿瘤直径一般较大,且不易发生淋巴转移,而且肿瘤病灶的大小对患者的预后有明显的影响.
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