• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependen

Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependen

来源 :The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议) | 被引量 : 0次 | 上传用户：testjmalt
【摘 要】
：
Background and aims EGFR activation and PKM2 expression are instrumental in tumorigenesis.EGFR activation regulates PKM2 functions in a subcellular compartment-dependent manner and promotes gene trans
【作 者】
：
B.Guleng Y.P.Liu J.L.Ren 
【机 构】
：
Department of Gastroenterology, Zhongshan Hospital affiliated to Xiamen University, 201 Hubin South
【出 处】
：
The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
【发表日期】
：
2014年5期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background and aims EGFR activation and PKM2 expression are instrumental in tumorigenesis.EGFR activation regulates PKM2 functions in a subcellular compartment-dependent manner and promotes gene transcription and tumor growth.In addition, PKM2 is upregulated in EGFR-induced pathways in glioma malignancies.However, we found that PKM2 could also regulate the activity of the EGF/EGFR signaling pathway in gastric cancer cells.We aimed to define the biological mechanisms for PKM2 in regulating the cell motility and invasion.
其他文献
Sequential therapy or standard triple therapy for Helicobacter pylori infection: A systematic review
Background The effectiveness of standard triple therapy (STT) for the eradication of Helicobacter pylori (HP) has decreased recently.Sequential therapy (SQT) is a new regimen proposed to address this
会议
MiR-19b reduces intestinal inflammation via down-regulation of colonic SOCS3 expression in Crohn
Background and aims The aim of our study was to investigate the contribution of SOCS3 expression-associated miRNA to modulate production of chemokine in intestinal epithelial cells and is associated w
会议
The efficacy of acupuncture in the treatment of functional dyspepsia: A systematic review and meta-a
Objective Functional dyspepsia (FD) is a common disease.Currently, there is no an established optimal treatment.The aim of this study is to assess the effect of acupuncture in relieving symptoms and i
会议
PI3K/Akt signaling pathway mediates IGF-1-induced N-cadherin up-regulation and cell migration in int
Objective To explore the effect and molecular mechanism of IGF-1 on cell migration in intestinal fibroblasts.Methods To evaluate the time effect of IGF-1 on cell migration,human intestinal fibroblasts
会议
Advanced glycation end products-mediated PKA inhibits RhoA/ROCK pathway activation: A possible mecha
Background and objective Colonic dysmotility is very common in diabetic patients.However, the mechanisms are only partially understood.The role of myopathy has gained significance over the past years,
会议
Serological investigation of food specific IgG antibodies in patients with inflammatory bowel diseas
Objective Dietary factors have been indicated to influence the pathogenesis and nature course of inflammatory bowel diseases (IBD) with their wide variances.The aim of the study was to assess the prev
会议
Circulating Nogo-B are correlated with liver cirrhosis
Aim To evaluate the significance of plasma Nogo-B levels in patients with liver cirrhosis.Methods Plasma Nogo-B levels were determined by enzyme linked immunosorbent assay (ELISA) in 301 patients with
会议
Systemic review and meta-analysis: Is a regimen containing tetracycline and amoxicillin suitable for
Objective To conduct a systematic review and meta-analysis of clinical trials with treatment in one study arm including both tetracycline and amoxicillin for eradication of Helicobacter pylori, thus p
会议
The function of protease activated receptor-2 in rat's NSAIDs enteropathy
Objective To research NSAIDs enteropathy rats intestinal epithelium mastocyte-enterocyte protease activated receptors-ERK signal transformation pathways, and to explore the function of protease activa
会议
Mindin attenuates the colon cancer progression both in vitro and in vivo via MAPK/ERK mediated manne
Aims Mindin is important in both innate and adaptive immunity.However, the role of Mindin during colon cancer development remains undefined.Methods Performed CCK-8, BrdU, flow cytometry and Transwell
会议