Popularly known as ‘macela or marcela,Achyrocline satureioides is a plant widely used by Brazilian folk medicine.Some of the biological effects attributed to this species are the digestive and hypoglycemic activities.Supercritical fluid extraction (SFE) is a technology that has been creating an increasing interest due to the advantages it provides when compared to traditional extraction methods,which frequently cause degradation and loss of target components,and might consume large volumes of environmentally non-friendly solvents.