【摘 要】
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Since the first tyrosine kinase inhibitor (Gleevec) was approved by FDA for treatment of CML, targeted tumor therapy has successfully opened an new avenue for the treatment of the cancer diseases.Such
【机 构】
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Richard J.Roberts Institute of Biotechnology in China China
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Since the first tyrosine kinase inhibitor (Gleevec) was approved by FDA for treatment of CML, targeted tumor therapy has successfully opened an new avenue for the treatment of the cancer diseases.Such therapy directs at specific, frequently occurring molecular alterations in the signaling pathways of cancer cells.Tyrosine kinases have crucial role in cell signaling and oncogenesis.It has been demonstrated that most of cancer drivers are tyrosine kinases.The characterization of molecular architectures and main functions of these proteins in tumorigenesis led to development of the novel drugs to interfere with specific cell signaling pathways and thus allow target-specific therapy for selected malignancies.
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