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Mammalian fatty acid 2-hydroxylase (FA2H) was recently identified and characterized.2-Hydroxy fatty acids (2-OHFA) generated by FA2H are utilized for synthesis of 2-hydroxysphingolipids, which are components of membrane rafts.Alternatively, 2-OHFA can be alpha oxidized in peroxisomes to generate odd chain length fatty acids.Our recent study demonstrated a role of FA2H in adipocyte differentiation and lipogenesis in mature adipocytes by modulation of raft fluidity and levels of GLUT4.