CAP1is associated with metastasis of NSCLC especially in brain metastasis patients

来源 :2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户:wuyan425
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  目的 Lung cancer ranks first in both prevalence and mortality rates among all types of cancer.The present study assessed thediagnostic and prognostic value of CAP1 for lung cancer.方法 Firstly,CAP1 were determined by PCR and western blot and IHC in 82 lung cancer specimens.BM group and non-BM groupwere treated and followed up by 4 years.ultivariate regression and KM survival analysis were performed to correlateimmunoreactive CAP1 signal with cancer type and stage.Secondly,to investigate the function of the CAP1 on the proliferation,migration and invasion of lung cancer cells in vitro and vivo of nude mice by knock down and over-expression CAP1.Thirdly,wemapped the S307D and S309D Phosphorylation sites of CAP1.To explore the relationship between CAP1 and Cofilin,Actin by IP,GST pull down assay,cell adhesion.
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