Synthesis and biological evaluations of Vandetanib derivatives containing an oxime-functionalized pi

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：zl9881123

【摘要】

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【作者】

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Rui Zhang Luxin Na Mingliang Liu

【机构】

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Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical Co

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

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2015年3期

【关键词】

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Vandetanib derivatives Synthesis Antitumor and antiviral activity

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　　Twenty one of Vandetanib derivatives containing an oxime-functionalized piperidine moiety were designed,synthesized and characterized by1HNMR,13CNMR,MS and HRMS.[1] One of them,IMB-1502 shows good activity against HSV-1 F(IC50: 0.82μg/mL)which is comparable to Acyclovir.Antiviral and antitumor activity of these target compounds is currently evaluated[2-5].

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Synthesis and biological evaluations of Vandetanib derivatives containing an oxime-functionalized pi

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