Six1 Homeoprotein Suppresses Human Colorectal Cancer Cells Growth by Inhibiting Wnt/-catenin Signali

来源 :2011第四届世界癌症大会 | 被引量 : 0次 | 上传用户:yun0558
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  Colorectal cancer (CRC) has become one of the leading causes of cancer-related deaths in Hong Kong.The overactive Wnt/β-catenin signaling may contribute to colorectal carcinogenesis by promoting proliferation, preventing apoptosis and enhancing the motile and invasive capabilities of tumor cells.Six 1, a nuclear homeodomain protein essential for the development of diverse tissues, has a close and complex association with Wnt/β-catenin signaling in various biological processes.
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