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Intracellular pathogens cause severe diseases in human and animals.The exact mechanism by which host cells effectively defend themselves against intracellular pathogens is largely unknown.Pore-forming proteins widely exist in vertebrates.Bacterial cholesterol-dependent cytolysin-type pore-forming proteins have been shown to plays a crucial role in innate immunity by directly killing pathogens (complement system) and infected-cells (perforin).