【摘 要】
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Objective:To observe the influence of deep hypothermic circulatory arrest (DHCA) on the apoptotic processes of neurons in the hippocampus and the expression of the related genes Bcl-2 and Bax,and to e
【机 构】
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Institute of Cardiovascular Surgery,Xijing Hospital,Fourth Military Medical University,Xi'an 710032
【出 处】
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第七届亚洲体外循环学术会议暨第三届全国体外循环学术会议
论文部分内容阅读
Objective:To observe the influence of deep hypothermic circulatory arrest (DHCA) on the apoptotic processes of neurons in the hippocampus and the expression of the related genes Bcl-2 and Bax,and to elucidate the mechanism of apoptotic brain injury caused by DHCA.Methods:Eighteen dogs were randomly divided into three groups:control group (6 animals,underwent normal temperature cardiopulmonary bypass,NCPB),DHCA group (6 animals,underwent DHCA for.1 h),and DHCA + IACP group (6 animals,underwent DHCA for 1 h,combined with intermittent antegrade cerebral perfusion (IACP) every 15min).
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