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AIM: To study the mechanism and effect of down-regulation of Histone Deacetylase 1 (HDAC1) by microRNA-520h in the chemotherapeutic effect of doxorubicin.METHOD: Down-regulation of HDAC1 by doxorubicin treatment was detected by western blot analysis.Quantitative RT-PCR and western blot were performed to find out the combination of HDAC 1and miR-520h.