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Hepatitis C virus(HCV) is the leading cause of liver fibrosis and cirrhosis which eventually worsen to liver cancer.There is urgent need to improve anti-HCV therapiesand discover novel therapeutic approaches in the form of new antiviral agents.1Chinese herbal extractsare possiblesources of potent anti-HCV agents.2We found echinocystic acid displayed substantial activity on HCV entry(IC50=~1uM)recently.β-Cyclodextrin(CD) is a well-known drug carrier and excipient for enhancing aqueous solubility.In this study,a series of novel β-cyclodextrin-triterpene conjugateswere designed and synthesized via ester bond or click chemistry.The anti-HCV activities of the conjugates were also investigated.