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  5. Influence of genetic polymorphisms of uptake (OATP1B1) and efflux (BCRP/MRP2) transporters on the ph

Influence of genetic polymorphisms of uptake (OATP1B1) and efflux (BCRP/MRP2) transporters on the ph

来源 :2013中国心脏大会(CHC) | 被引量 : 0次 | 上传用户：xxm181512619
【摘 要】
：
Objective The aim of the present study was to investigate the contribution of genetic polymorphisms of uptake (OATP 1B1) and efflux (BCRP/MRP2) transporters on the pharmacokinetics of rosuvastatin in
【作 者】
：
Lei Tian Juanjuan Jiang Hong Liu Lulu Han Yiling Huang Yishi Li 
【机 构】
：
Key Laboratory of Clinical Trial Research in Cardiovascular Drugs,Ministry of Health,Fu Wai Hospital
【出 处】
：
2013中国心脏大会(CHC)
【发表日期】
：
2013年2期
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Objective The aim of the present study was to investigate the contribution of genetic polymorphisms of uptake (OATP 1B1) and efflux (BCRP/MRP2) transporters on the pharmacokinetics of rosuvastatin in Chinese subjects, and provide molecular mechanism to the individual differences in drug disposition and response caused by membrane transporters.
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