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Diabetic foot ulcer (DFU), caused by impaired wound healing, is a common vascular complication of diabetes.However, the pathogenesis of wound healing deficiency in diabetes has not been well understood.The present study revealed that the plasma level of pigment epithelium-derived factor (PEDF), a serine proteinase inhibitor (Serpins) with anti-angiogenic activity, was elevated in Type 2 diabetic patients withDFU.To test whether elevated PEDF levels contributes to skin wound healing delay in diabetes, endogenous PEDF was neutralized with an anti-PEDF antibody in db/db mice.