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目的 多种TRIM 家族蛋白质具有RING-指结构域而具有E3 泛素连接酶活性，称为E3 泛素连接酶.TRIM29 属于TRIM 蛋白家族的成员，与肿瘤的发生、发展密切相关.
TRIM29缺失通过加速CAPN3介导的ISG15的加工抑制胰腺导管腺癌的干细胞样特征
【摘 要】
：
目的 多种TRIM 家族蛋白质具有RING-指结构域而具有E3 泛素连接酶活性，称为E3 泛素连接酶.TRIM29 属于TRIM 蛋白家族的成员，与肿瘤的发生、发展密切相关.
【机 构】
：
中国医科大学
【出 处】
：
2019中国肿瘤学大会
【发表日期】
：
2019年7期
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