【摘 要】
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I widely conducted a screening to detect to substances that are potentially useful for the feasibility of chemopreventive natural sources against all type cancers.In the process of our in vitro and in
【机 构】
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Graduate School of Medicinal Science Kanazawa University Japan
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I widely conducted a screening to detect to substances that are potentially useful for the feasibility of chemopreventive natural sources against all type cancers.In the process of our in vitro and in vivo conventional assay for anti-tumor promoters/chemopreventive agents, the application of a new screening procedure which utilizes the synergistic effect of short-chain fatty acids and tumorpromoting diterpene esters, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) enabled rapid and easy detection of naturally occurring substances (anti-tumor promoters, chemopreventive agents) with inhibition of Epstein-Ban-virus (EBV) activation/tumor-promoting potency, using human lymphoblastoid cells, Raji cells.On basis of these results, we have now extended these investigations to a informative tumorigenesis model in which we initiated the tumors with DMBA initiation and promoted with 1.7 nmol of TPA in two-stage mouse skin test and other models.These results provide a basis for further development of these natural sources for human cancer chemoprevention and for the design of clinical studies.
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