【摘 要】
：
Hepatitis C virus(HCV) is the leading cause of liver fibrosis and cirrhosis which eventually worsen to liver cancer.There is urgent need to improve anti-HCV
【机 构】
：
State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Hepatitis C virus(HCV) is the leading cause of liver fibrosis and cirrhosis which eventually worsen to liver cancer.There is urgent need to improve anti-HCV therapies and discover novel therapeutic approaches in the form of new antiviral agents.1 Fullerene has been attracting considerable attention in medicinal and material chemistry due to its unique physical and chemical properties.2 In this study,an α-cyclodextrin-[60]fullerene conjugate with a flexible linker at the secondary face of α-cyclodextrin has been prepared,which displays significant water solubility and,more importantly,acts as a new class of HCV entry inhibitor with IC50 at 0.17 tM level.
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