Antibacterial Drug Discovery and Development Programs at NIAID

来源 :中国上海第七届国际新药发明科技年会 | 被引量 : 0次 | 上传用户:hanfeizifly
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  In support of antibacterial drug discovery and development,the National Institute of allergy and Infectious Diseases (NIAID) has been funding programs coveting basic research,target identification,assay development,high throughput screens,lead optimization,pre-clinical studies,clinical studies,and clinical trials.NIAID also provides services to facilitate translational research with resource and technology with the goal of lowering barriers to entering the product development pipeline.The overall goals of these discovery and development efforts are to control,prevent,and treat diseases caused by infectious pathogens including antimicrobial resistance organism through the combined efforts of academia,industry,and government.This is particularly important in these times of rapid emergence of antimicrobial resistance with diminishing treatment options for selected pathogens.
其他文献
  The peptide motilin has a pronounced effect on gastrointestinal motility and is involved in the regulation of the so called "migrating motor complex (MMC)"
会议
高脚白为涿州市大葱的当家品种。目前经过提纯复壮 ,产量、品质有了同步提高 ,每年种植面积均在万亩以上 ,一般平均667 (亩)可产3500 (公斤) ,高达5000 以上。高脚白大葱株高1m(米)左右 ,不分
  Classical antibiotics target vital cell functions,but this strategy has led to the development of multi-resistant microbes and we are running out of options
会议
  Gene-expression profiling using whole-genome microarray screening holds the promise of revealing molecular mechanisms and biomarkers of neurodegenerative di
会议
  The monoclonal antibody (mAb) D32.10 generated by HCV particles recognizes a discontinuous epitope encompassing three regions E1 (aa297-306),E2A(aa480-494)
会议
目的研究静脉溶栓桥接TREVO支架取栓治疗颈动脉T型闭塞脑梗死患者的临床效果和安全性。方法回顾性分析2017年9月至2019年9月许昌市中心医院收治的51例颈内动脉T型闭塞脑梗死患者的临床资料,根据治疗方法分为对照组(单纯静脉溶栓组,29例)和观察组(静脉溶栓桥接TREVO支架取栓组,22例)。比较两组患者治疗后的血管再通率、美国国立卫生院卒中量表(NIHSS)评分、90 d改良Rankin量表(
你一定有过这样的感觉:旁边好像有东西在走动脊背发减后面有人呼气,但后面并没有人……从古至今,总有人相信死者的灵魂会在其丧生之地或葬身之所徘徊游荡,古希腊哲学家柏拉图也是
  Hepatitis C virus infection remains a major medical problem with approximately 200 million people world wide living with the disease.The current standard of
会议
  There is a well recognized need for new antibacterial agents to fight resistant bacteria,such as MRSA and VRE.The inhibition of novel essential cell-wall ta
会议
本文调查结果反映出所调查的汉族组老人摄入食物的种类与大多数食物的摄入量都明显高于维吾尔族组老人,但汉族组老人碳水化合物摄入量偏低,脂肪摄入量偏高,总热能摄入量高于