The use of FISH for detection of chromosomal abnormalities in myelodysplastic syndrome--A Prospectiv

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户:hudan913000
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective To evaluate the effect of FISH studies and conventional G-banding analysis in detecting chromosomal abnormalities in MDS patients.Methods 1132 bone marrow samples were obtained from 957 patients diagnosed with MDS in University of Nebraska Medical Center (UNMC) from January 1,2003 to December 31,2010.
其他文献
Purpose Minimal residual disease (MRD) detected by multiparametric flow cytometry is an important method for predicting relapse.According to the dynamic changes of MRD,through the first clinical treat
会议
Purpose To establish a method for detecting minimal residual disease (MRD) by eight color flow cytometry which is stable,repeatable and accurate quantitation.Method According to the ratio of 10%,1%,0.
会议
Backgroud Familial hemophagocytic lymphohistocytosis (FHL) is a genetic disorder oflymphocyte cytotoxicity that usually presents in the first two years of life and has a poor prognosisunless treated b
会议
Jak2 is a nonreceptor tyrosine kinase belonging to the Janus (Jak) family of tyrosine kinases.The JAK2 V617F mutation renders the kinase constitutively active and leads to the human myeloproliferative
会议
Objective The reduced expression of CTNNA1 gene,a putative tumor suppressor gene,has been found in several cancers including acute myeloid leukemia (AML).CTNNA1 expression is regulated by methylation
会议
Objective Predicting survival in persons with primary myelofibrosis (PMF) is typically based on the International Prognostic Scoring System (IPSS),the Dynamic IPSS (DIPSS) or the DIPSS-Plus.These scor
会议
Objective Previous reports regarding the association between alcohol intake and the risk of myelodysplastic syndromes (MDS) have been inconclusive.We conducted a meta-analysis to evaluate alcohol inta
会议
Objective CTNNA1 gene is a putative tumor suppressor for its roles in inhibiting proliferation and promoting apoptosis.Aberrant expression of CTNNA1 is regulated by epigenetic mechanisms including bot
会议
Objective Pesticide exposure has been linked to increase risk of cancer at several sites,but its association with risk of myelodysplastic syndromes (MDS) is still inconsistent.A meta-analysis of studi
会议
Objective The myelodysplastic syndromes (MDS) constitute a group of heterogeneous clonal haemopoietic stem cell disorders,characterized by ineffective and dysplastic haematopoiesis with varying degree
会议