【摘 要】
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Background: Pregnancy is a special immunological event.The crosstalk between different kinds of cells and molecules in the maternal-fetal interface is the key of maternal-fetal immune regulation resea
【机 构】
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Department of Immunology, Binzhou Medical University, Shandong, China;Hospital and Institute of Obst
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Background: Pregnancy is a special immunological event.The crosstalk between different kinds of cells and molecules in the maternal-fetal interface is the key of maternal-fetal immune regulation research.To explain the interaction among the trophoblasts, maternal decidual stromal cells and immune cells is important for the research of mechanisms in maternal-fetal immune tolerance during pregnancy.LAIR-1 belongs to the inhibitory receptors family, which are involved in controlling the immune balance to prevent improper activation.Upon interaction with their ligands-collagen, LAIR-1 can attenuate the signals provided by activatory receptors, thereby increasing the threshold for activation.More than 70％ of decidual immune cells (DICs) are CD56brightCD16 decidual NK which play a very important role in the maternal-fetal immune tolerance.However, there is no research to illustrate the regulatory roles of the collagens/LAIR-1 interaction in the function of decidual natural killer cells (dNK) and the intracellular signal transduction pathway.
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