The inherent multi-physics and multi-scale features of many real world problems accentuate the importance to develop efficient and stable numerical methods for the relevant PDEs,especially the decoupling methods.Although great efforts have been made for solving these problems,many practical and analytical challenges remain to be solved.This mini-symposium intends to create a forum for junior and senior researchers from different fields to discuss recent advances on the decoupling methods for multi-physics and multi-scale problems with their applications.