Carfilzomib,a structural analogue derived from natural product epoxomicin that wasapproved by US FDA for the treatment of relapsed and refractory multiple myeloma[1-3].
A new series of multitarget-directed edaravone derivatives were designed and synthesized.Rational pharmcophore-directed design strategy was undertaken and antioxidant edaravone was combined with the a
Increaseing HIF-1α levels after ischemic stroke cells can protect damaged nerves,reduce disability mortality.HIF-1α is ubiquitinated and degradated by the von Hippel-Lindau protein(pVHL).However,the s