【摘 要】
：
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been listed as the most toxic organic pollutant.However,report on its poisoning case was rare.In this study,toxic
【机 构】
：
DepartmentofChemistry,HongKongBaptistUniversity,Kowloon,HongKongSAR,China
【出 处】
：
全国生物医药色谱及相关技术学术交流会(2012)
论文部分内容阅读
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been listed as the most toxic organic pollutant.However,report on its poisoning case was rare.In this study,toxic effect of TCDD in blood,liver and skeletal muscle tissues of C57BL/6J (C6) and DBA/2J (D2) mice was investigated by using LC-QTOFMS-based metabolomics.With the non-targeted approach in conjunction with multivariate data analysis,hundreds of ions were aligned and extracted with P-value and fold-change in mice exposed to TCDD compared to control group.As a result,in the aryl hydrocarbon receptor (AhR)-sensitive mouse model-C6,fatty acid beta-oxidation was markedly enhanced.Meanwhile,perturbation of other metabolic pathways was also observed,namely the accumulation of fatty acids and lysophospholipids,the reduced amino acid biosynthesis and the decreased purine metabolism.In contract,in the less-sensitive mouse model-D2.
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