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  5. Exploring the Gating Mechanism of the Calcium Release-Activated Calcium Channel with Molecular Dynam

Exploring the Gating Mechanism of the Calcium Release-Activated Calcium Channel with Molecular Dynam

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：evemxy
【摘 要】
：
　　Calcium release-activated calcium(CRAC)channels in the plasma membrane are integral membrane proteins that is critical in cellular signaling by generating t
【作 者】
：
Hao Dong 
【机 构】
：
KuangYamingHonorsSchool,NanjingUniversity,P.R.China
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
【发表日期】
：
2016年10期
【关键词】
：
ion channel calcium MD simulations gating mechanism 
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　　Calcium release-activated calcium(CRAC)channels in the plasma membrane are integral membrane proteins that is critical in cellular signaling by generating the sustained influx of calcium.The crystal structure of Orai[1],the pore unit of a CRAC channel from Drosophila melanogaster at 3.35(A)resolution,provides the first insight into the architecture of this transmembrane protein at atomic level.
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