【摘 要】
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Background, Motivation and Objective Quantitative Ultrasound (QUS) is a promising technique for bone tissue evaluation. Highly focused transducers, used for QUS, have also a capability to be applied f
【机 构】
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Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaet Berlin, Berlin, Germany
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Background, Motivation and Objective Quantitative Ultrasound (QUS) is a promising technique for bone tissue evaluation. Highly focused transducers, used for QUS, have also a capability to be applied for tissueregenerative purposes and can provide geometrically controlled deposition of an accurate acoustic dose. This allows for overcoming of unwanted artifacts, i.e. standing waves, ring interferences, temperature elevations, cross-stimulation of adjacent wells, which often lead to irreproducible biological results, associated with existing Low- Intensity Pulsed Ultrasound (LIPUS) in-vitro set-ups. Focused LIPUS (FLIPUS) is a novel reliable tool, which is not prone to the aforementioned artifacts. This study aimed at the analysis of mechanical response in murine C2C12 myoblastic cells, possessing osteogenic-lineage differentiation potential, upon exposure to well controlled FLIPUS dose.
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