Presence of CD34+CD38-CD58-Leukemia-Propagating Cells at Diagnosis Identifies Patients at High-risk

来源 :2014天津国际干细胞论坛 | 被引量 : 0次 | 上传用户:InsideASPNET
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aims:Relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) results from the persistence of leukemic stem cells,termed leukemia-propagating cells (LPCs).In Ph+ALL,we recently identified that LPCs are enriched in the CD34+CD38-CD58-fraction by a xenograft assay (Kong Yet al.
其他文献
Tumor-associated macrophages (TAMs) are widely studied in solid tumors.The distribution of macrophages in lymph node samples was found to be associated with prognosis in lymphomas.
会议
Acute myeloid leukemia (AML) is a hematological malignancy resulting from the transformation of normal hematopoietic stem cell (HSC).Except for the intrinsic factors,it is acceptable that some extrins
会议
Generating engraftable hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) is an ideal approach to get induced HSCs (iHSCs) for regenerative medicine.
会议
The wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) negatively regulates several tumor suppressor and DNA damage response pathways,which have been implicated in stem cell function and aging.
会议
The balance between primitive and mature blood cells is governed by both intrinsic and extrinsic factors.However,this balance can be severely disrupted in disease conditions,such as leukemia.
会议
Cardiac resident stem cells (CSCs) represent a responsive stem cell reservoir within the adult myocardium and recent studies have revealed that CSCs have a significant function in myocardial hemostasi
会议
Among cyclin-dependent kinase inhibitors (CKIs) that control the G1 phase in cell cycle,only p18 and p27 can negatively regulate hematopoietic stem cell (HSC) self-renewal.
会议
Immuno-compromised mice,such as the non-obese diabetic/severe combined immune-deficient (NOD/SCID) mice,have been widely used to examine the in vivo self-renewal and differentiation of human hematopoi
会议
T-cell acute lymphoblastic leukemia (T-ALL) is accounted for about 25% of adult ALL and 10-15% of childhood ALL.Hyper-activation of the PI3K/Akt/mTOR pathway sustains Notch1 mutation induced T-ALL via
会议
Purpose:To establish a leukemia-therapy model,and study the changes of hematopoietic stem/progenitor cells and their leukemic companions post therapy.
会议