【摘 要】
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Rapamycin is a macrocyclic polyketide compound exhibiting immunosuppressive, anticancer,and antifungal activity.It is clinically important for treatment of orga
【机 构】
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ShanghaiInstituteofPharmaceuticalIndustry.No.1320,WestBeijingRoad,Jing'anDistrict,Shanghai200040,Ch
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Rapamycin is a macrocyclic polyketide compound exhibiting immunosuppressive, anticancer,and antifungal activity.It is clinically important for treatment of organ transplant rejection and autoimmune disease, as well as anticancer drug discovery.The biosynthesis mechanism and regulation of rapamycin were focused on its biosynthesis gene cluster cloned from Streptomyces hygroscopicus ATCC29253 in 1995.Another natural rapamycin producer Actinoplanes.sp.
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