【摘 要】
：
目的 BSG (basigin)基因编码CD147蛋白,该蛋白也被称为EMMPRIN (Extracellular matrix metailoproteinase inducer).CD147是膜蛋白,包含一段约23个氨基酸组成的跨膜区,在正常皮肤中主要在角质形成细胞的胞膜上有表达.而在包括皮肤癌在内的多种肿瘤中被发现表达增高.本研究发现CD147在黑素瘤中存在大量胞浆表达,并且在转移癌组织中的
【机 构】
：
中南大学湘雅医院皮肤科 410078
【出 处】
：
中华医学会第二十次全国皮肤性病学术年会、国际特应性皮炎、皮肤病遗传、银屑病国际论坛
论文部分内容阅读
目的 BSG (basigin)基因编码CD147蛋白,该蛋白也被称为EMMPRIN (Extracellular matrix metailoproteinase inducer).CD147是膜蛋白,包含一段约23个氨基酸组成的跨膜区,在正常皮肤中主要在角质形成细胞的胞膜上有表达.而在包括皮肤癌在内的多种肿瘤中被发现表达增高.本研究发现CD147在黑素瘤中存在大量胞浆表达,并且在转移癌组织中的胞浆表达更为明显.本研究的目的即为阐明黑素瘤组织中胞浆CD147的生物学功能及其在黑素瘤侵袭转移中的角色.
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