【摘 要】
：
Since 2008, our Institution starting using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) material for molecular testing of lung adenocarcinomas.Patients with a diagnosis
【机 构】
：
Department of Pathology Ohio State University Medical Center USA
论文部分内容阅读
Since 2008, our Institution starting using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) material for molecular testing of lung adenocarcinomas.Patients with a diagnosis of adenocarcinoma were reflexively tested for molecular markers by polymerase chain reaction, sequencing, and fluorescence in situ hybridization (FISH).The testing panel from simple EGFR, KRAS and ALK to Lung Carcinoma Molecular Panel (AKT1, BRAF, EGFR, ERBB2,HRAS, KRAS, MET, NRAS, PIK3CA, STK11, TP53 utilizing the Ion AmpliSeqTM Cancer Hotspot Panel v2 and MEK1 utilizing Sanger Sequencing) by Next Generation Sequencing and Sanger Sequencing Analysis.
其他文献
Radiation therapy is a common treatment option for head-and-neck cancer.During the course of external beam radiotherapy of 6-7 weeks, interfraction anatomic changes (tumor regression, weight loss, etc
Carbon-ion radiotherapy (C-ion RT) offers superior dose distribution in the treatment of tumor volume compared with conventional X-ray radiotherapy.In addition, carbon-ion beam has a higher relative b
Current radiotherapy treatments such as IMRT and VMAT have undergone extensive development and are now reaching to a point of diminishing return.Several technical and clinical advances have called for
The mechanism of radiation-induced delayed brain injuries remains poorly understood, and few treatment options are available.The aim of this study was to investigate whether temporal lobe necrosis can
The interaction between mesenchymal stem cells (MSCs) and dendritic cells (DCs) affects T cell development and function.Further, the chemotactic capacity of MSCs, their interaction with the tumor micr
Research on imaging contrast media over the last decades has led to the discovery of small molecular necrosis-avid compounds (NACs) for the diagnosis of myocardial infarction and therapeutic assessmen
Immunological and biological cancer therapy is now deployed in many settings and is beginning to improve outcomes for cancer patients.There is a pressing need for further innovation and we have develo
Antibody drug conjugate (ADC) is a new class of targeted therapeutics that shows promise in regressing cancers that are resistant to current treatments.In the most simplistic term, an ADC is analogous
We evaluated the safety issues raised by the risk of p53TCR gene transfer-associated on/off-target toxicities in relevant mouse models of adoptive transfer.We provide evidence that an optimized high-a
Leukemia can be classified into lymphoid and non-lymphoid leukemia.The non-lymphoid leukemia can further be classified into acute and chronic ones.A unique kind of compounds were developed that could