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Objective: Platinum based doublet chemotherapy is standard treatment for treatment na(i)ve advanced NSCLC pts, although molecularly targeted therapy can improve outcome of selected patients who harbors driver gene mutation.S-1, a oral fluoropyrimidine, has been investigated to treat NSCLC.S-1 was active enough to show non-inferiority in two randomized phase Ⅲ trials either in combination with Carboplatin and Cisplatin (CDDP) compared with the standard platinum doublet chemotherapy in Japanese pts with NSCLC.