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  5. Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric

Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric

来源 :国际精准医疗与未来健康前沿研讨会暨全国第三届药物基因组学学术大会 | 被引量 : 0次 | 上传用户：ntsx888
【摘 要】
：
Nude mice are important in vivo model for characterization of cell malignancy behavior;however,many cancer cells fail to form tumors in it.Understanding this defective mechanism may provide novel insi
【作 者】
：
吕有勇 
【机 构】
：
北京大学肿瘤医院
【出 处】
：
国际精准医疗与未来健康前沿研讨会暨全国第三届药物基因组学学术大会
【发表日期】
：
2015年10期
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Nude mice are important in vivo model for characterization of cell malignancy behavior;however,many cancer cells fail to form tumors in it.Understanding this defective mechanism may provide novel insights into tumorigenesis and how tumor cells escape innate immunity.Whole-genome sequencing was conducted on two gastric cancer (GC) cells, BGC823 and AGS,which do and do not form tumors in nude mice, to identify their genomic differences relevant to natural killer (NK) cells.
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