【摘 要】
：
Tuberculosis is today amongst the worldwide health threats.As resistant strains of Mycobacterium tuberculosis have slowly emerged,treatment failure is too often a fact.Discovery of new efficient drug
【机 构】
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Director of Research CNRS France
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Tuberculosis is today amongst the worldwide health threats.As resistant strains of Mycobacterium tuberculosis have slowly emerged,treatment failure is too often a fact.Discovery of new efficient drug becomes pressing.In this context,we consider automatic synthesis to generate quickly a large quantity of new antitubercular candidates.Two families of compounds potentially efficient against molecules involved in biosynthesis of Mycobacterium tuberculosis cell wall and essential for tuberculosis bacillus survival were designed,synthesized and some of them have given encouraging biological activity.Some encouraging results were obtained earlier in our group.1 Thus,a three step and a four step protocol have been designed for the synthesis of 3-(2-(4-alkoxyphenyl)ene-yl)-[1,2,4-]triazolo[3,4-a]phthalazines and 3-(2-(4-alkoxyphenyl)cyclopropyl)-[1,2,4-]triazolo[3,4-a]phthalazines.
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