Synthesis of Novel β-cyclodextrin-Triterpene Conjugates as HCV Entry Inhibitors

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：jzsoft

【摘要】

：

【作者】

：

Sulong Xiao Qi Wang Fei Yu Yiyun Peng Yongmin Zhang Li-he Zhang Demin Zhou

【机构】

：

State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100191

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　Hepatitis C virus(HCV) is the leading cause of liver fibrosis and cirrhosis which eventually worsen to liver cancer.There is urgent need to improve anti-HCV therapiesand discover novel therapeutic approaches in the form of new antiviral agents.1Chinese herbal extractsare possiblesources of potent anti-HCV agents.2We found echinocystic acid displayed substantial activity on HCV entry(IC50=~1uM)recently.β-Cyclodextrin(CD) is a well-known drug carrier and excipient for enhancing aqueous solubility.In this study,a series of novel β-cyclodextrin-triterpene conjugateswere designed and synthesized via ester bond or click chemistry.The anti-HCV activities of the conjugates were also investigated.

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Synthesis of Novel β-cyclodextrin-Triterpene Conjugates as HCV Entry Inhibitors

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