【摘 要】
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Midbrain dopamine neurons are an essential component of the basal ganglia circuitry,playing key roles in the control of fine movement and reward.Recently,it has been demonstrated that g-aminobutyric a
【机 构】
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Department of Neurosurgery,Department of Neurology and Neurological Sciences,Stanford University
【出 处】
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第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Midbrain dopamine neurons are an essential component of the basal ganglia circuitry,playing key roles in the control of fine movement and reward.Recently,it has been demonstrated that g-aminobutyric acid(GABA),the chief inhibitory neurotransmitter,is co-released by dopamine neurons.Here,we show that GABA co-release in dopamine neurons does not use the conventional GABA-synthesizing enzymes,glutamate decarboxylases GAD65 and GAD67.Our experiments reveal an evolutionarily conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1(ALDH1a1).Moreover,GABA co-release is modulated by ethanol(EtOH)at concentrations seen in blood alcohol after binge drinking,and diminished ALDH1a1 leads to enhanced alcohol consumption and preference.These findings provide insights into the functional role of GABA corelease in midbrain dopamine neurons,which may be essential for reward-based behavior and addiction.
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