【摘 要】
：
Non-motor symptoms are of vital importance in Parkinsons disease in recent years.These symptoms occur far early before the motor dysfunction in PD.However,the mechanisms underlying these non-motor sym
【机 构】
：
Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurol
【出 处】
：
第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Non-motor symptoms are of vital importance in Parkinsons disease in recent years.These symptoms occur far early before the motor dysfunction in PD.However,the mechanisms underlying these non-motor symptoms are largely unknown.In rotenone-induced PD rats,there was a gradual reduction in the number of nigral dopaminergic neurons after rotenone treatment.Meanwhile,changed cardiovascular function was observed in the early stages.The loss of catecholaminergic neurons in the rostral ventrolateral medulla emerged earlier than the nigral dopaminergic neurons,neither that of the caudal ventrolateral medulla nor the nucleus tractus solitarii.In PD transgenic mice expressing mutant human alpha-synuclein,loss of cholinergic neurons in the dorsal motor nucleus of the vagus nerve were observed far earlier than that of the dopaminergic neurons and lower plasma ghrelin levels were also observed at this stage.In PD patients at stage Ⅰ-Ⅲ,plasma ghrelin levels were decreased in both genders,and ghrelin suppression and next preprandial peak related to glucose delivery were both attenuated.These suggest that non-motor symptoms occur early because of the impairment of cardiovascular and gastrointestinal center in the brain stem in PD.
其他文献
The receptive field is one of the most common ways to characterize the function of a neuron in a sensory system.To encode sensory stimuli,cells typically collect information across their receptive fie
Precise timing is critical for motor control such as singing and speech.Chain networks,in which groups of neurons form feed-forward networks that support sequential activations of successive neurons,a
With the technology advancing,we are accumulating data at the molecular,cellular,tissue,behavior and environmental level.As a consequence,how to first identify(disease)roots at various levels and then
Humans and monkeys have access to an accurate representation of visual space despite a constantly moving eye.One mechanism by which the brain accomplishes this is by remapping visual receptive fields
My research goal is to develop mass spectrometry-based proteomics and systems biology approaches to address biomedical challenges.Wehave developed a quantitative proteomics pipeline,capable of analyzi
Yes-associated protein(YAP)is a key transcriptional cofactor of the Hippo pathway,critical for the development of multiple organs.However,its role in the developing brain remains poorly understood.Her
Histone variants as important epigenetic regulators play important roles in development.However,it is still unknown that how histone variant H2AZ regulates cortical neurogenesis during brain developme
Glycogen synthase kinase-3β(GSK-3β)is a key regulator of many cellular signaling pathways.In the dopamine(DA)system,GSK-3β is particularly involved in D2 receptor(D2R)-mediated signaling.We and others
Small packaging capacity has limited therapeutic use of AAV in genetic disease caused by large genes such as cysic fibrosis.A novel trans-splicing strategy was designed to overcome the size constraint
Hippocampal long-term potentiation(LTP)can be temporally and mechanistically classified into early phase LTP(E-LTP)and late phase LTP(L-LTP).While the non-decaying nature of L-LTP is thought to be dep