Objective: To investigate the method, curative effect, and safety of interventional therapy for lung cancer patients with superior vena cava syndrome (SVCS).Methods: A total of 52 cases of lung cancer patients with SVCS who received interventional therapy between January 2011 to December 2011 were observed.Of the 52 cases, superior vena cava stent implantation was successfully performed in 50 cases.Obstructive changes of the distal venous pressure were measured before and after angioplasty, and the results were illustrated with matched-pair test.In addition, the curative effect and postoperative survival rate of these 50 patients upon follow up were determined.