【摘 要】
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To observe expression of HCN4 channel in both normal and overactive bladder (OAB)rats.Evaluate the function of the HCN4 channel in the OAB bladder and discuss the relationship between HCN4 and bladder
【机 构】
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The Second Affiliated Hospital,Xi'an Jiaotong University
【出 处】
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第十三届亚洲泌尿外科学会年会(UAA2015)、第二十二届全国泌尿外科学术会议(CUA2015)、第十六届全军及武警泌尿
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To observe expression of HCN4 channel in both normal and overactive bladder (OAB)rats.Evaluate the function of the HCN4 channel in the OAB bladder and discuss the relationship between HCN4 and bladder dysfunction.Divided the experimental rats into normal control group and OAB group(4w,6w,8w) after establishing the rats model of overactive bladder successfully.By immunohistochemical detection and Western blot methods,observe the expression of HCN4 in both normal rats and OAB rats.This study indicated that HCN4 expression was significantly increased in OAB rats compared to that in normal rats,especially in the 8w group, by immunohistochemical detection and Western blot.HCN4 expression was up-regulated in OAB rats compared to the normal rats makes a point of telling us that HCN4 may play an important role in the mechanism of OAB bladder, silencing HCN4 expression may be a new therapeutic strategy against OAB in the future.
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