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Chronic hypoxia is a considered for inducing Pulmonary artery hypertension (PAH) and play an important role in the progress of PAH.At present, it is possible for using the recombinant eNOS gene in the therapy of PAH.Endothelial progenitor cells (EPCs) is thought to take part in the formation of vessels not only in the embryonic period, but also after born.The dysfunction of EC is critical in the mechanism of PAH, so the hypothesis of target transplanting the EPCs will be an ideal method.