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  5. Mitochondira Omi/HtrA2 enhanced myocardial ischemia/reperfusion injury in aging rats

Mitochondira Omi/HtrA2 enhanced myocardial ischemia/reperfusion injury in aging rats

来源 :International Conference for Physiological Sciences 2012(201 | 被引量 : 0次 | 上传用户：jianqing3232
【摘 要】
：
The increased rate of myocardial apoptosis in the aging heart exacerbates myocardial ischemia/reperfusion (MI/R) injury.Our research found the increased expression of Omi/HtrA2, a potent mitochondrial
【作 者】
：
Ke Wang Suli Zhang Xiuliang Ma Huirong Liu Yuexing Yuan Lin Zuo Xiaoliang Wang Jianyu Shang Kehua Bai Lu Ma Xing Liu Xiao Li 
【机 构】
：
Department of Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing,Ch
【出 处】
：
International Conference for Physiological Sciences 2012(201
【发表日期】
：
2012年8期
【关键词】
：
Omi/HtrA2 aging myocardial ischemia/reperfusion 
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　　The increased rate of myocardial apoptosis in the aging heart exacerbates myocardial ischemia/reperfusion (MI/R) injury.Our research found the increased expression of Omi/HtrA2, a potent mitochondrial proapoptotic protein, enhanced MI/R injury in aging rat hearts.However, the mechanisms responsible for this agerelated pathologic change remain unclear.The aim of our study was to identify whether mitochondrial Omi was involved in age-related apoptosis through not only its leakage from mitochondria to cytosol but also through the degredation of some anti-apoptotic proteins in mitochondria.
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