【摘 要】
：
Schwannt has are tumors arising from Schwann cells of the peripheral or cranial nerves.Schwannomas,although benign,call be fatal or give rise to significant morbidity due to an unpredictable growth ra
【机 构】
：
Laval University & CHUL Canada
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Schwannt has are tumors arising from Schwann cells of the peripheral or cranial nerves.Schwannomas,although benign,call be fatal or give rise to significant morbidity due to an unpredictable growth rate.They can reoccur after surgery or radiation as current treatments,however each with significant inherent risks.These risks are further augmented in neurofibromatosis type 2 (N2F),a germ line predisposition syndrome characterized by multiple schwannomas.Hence,underlying the need for biological targeted therapies.Gleevec (STI571,imatinib mesylate),in addition to the bcr-abl oncogene in chronic myelogenous leukemia,inhibits the c-kit and platelet-derived growth factor receptor (PDGFR) signaling pathways,thereby expanding its use to several malignant and benign human diseases.In this study,we investigated whether Gleevec can be a potential drug in the treatment of human sporadic and N2F-associated schwannomas.
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