【摘 要】
:
Chromosome 17 is frequently abnormal in breast cancer.Several genes important to breast cancer treatment and prognosis reside on this chromosome, including
【机 构】
:
Core Pathology lab for the Cancer Research and Therapy Center University of Texas Health Science Cen
【出 处】
:
(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
论文部分内容阅读
Chromosome 17 is frequently abnormal in breast cancer.Several genes important to breast cancer treatment and prognosis reside on this chromosome, including HER2, topoisomerase Ⅱ α and P53.In previous studies, we analyzed breast cancers using bacterial artificial chromosome arrays and showed that results of HER2 analysis by comparative genomic hybridization arrays are accurate and robust in a clinical validation study (Yeh et al, Modem Pathology 2009,May 15 Epub).With the more recent availability of oligorarrays with increased probe density, we can further analyze chromosome 17 in breast cancers with greater precision.In this study, 100 frozen samples of invasive lobular and invasive ductal carcinoma, with known immunohistochemistry and fluorescence in situ hybridization results for HER2,were analyzed by comparative genomic hybridiz.ation to a commercially available oligoarray.We demonstrate the results of analysis of chromosome 17, with attention to the HER2 amplicon and the centromere region, as well as other genes of interest, such as topoisomerase Ⅱ α.
其他文献
近年来,随着国家经济的快速增长,在提升国民生活水平的同时,使得人们对用电需求量也在不断增大.为了保证电力系统运行的稳定性与安全性,加强变电检修工作效率是至关重要的.变
针对目前农村初中生辍学的情况,本文依据调查从家庭、学校和学生三个方面分析农村初中生辍学的原因,以便给以探讨、研究农村初中生辍学的同行或专家帮助、参考.
The breast cancer tumor suppressor, BRCA1, is mutated in many familial breast cancers and functions in the cell nucleus and at the centrosome to regulate DN
生活化教学是幼儿教育最常用的理念,而游戏是幼儿们最喜欢的学习方式,幼师要积极开展生活游戏化教学,运用幼儿熟悉的生活场景来设计游戏,让幼儿在游戏中掌握知识.幼师要编创
In the last decade the number of breast cancer patients presenting with early stage disease has increased.The results from multiple randomized breast cancer
随着新课改的深入推进,小学语文教学方法也在不断进行着革新.在此形势下,高效化、多元化的教学方法被广泛应用于小学语文课堂,不但有效提升了小学语文的教学效果,而且也进一
信息技术的快速发展带动了各行各业的发展.将信息技术融入到教育领域,可以丰富教学内容、拓宽教学的形式、补充教学资源.在高中语文课堂教学中,教师采用的信息技术大多是以多
课程体系是构建人才培养方案的核心内容,对实现专业群人才培养目标起关键作用.文章分析产教融合背景下中职财经商贸类专业群课程体系现状与不足,并提出对策.
高职院校内部质量体系诊断与改进共有学校、专业、课程、教师和学生五个层面.本文以高职学校环保类专业中的《化学分析》课程为例,从课程基本情况、两链打造、实施运行、存在
正在排版中,传来敬爱的邓小平同志逝世的噩耗。大型电视文献纪录片《邓小平》撰稿人之一、中共中央文献研究室副研究员高屹同志为我刊写来的这篇专稿竟成为深切的怀念之文。