来自内生真菌Penicillium citrinum的两个新糖苷类化合物

来源 :中国化学会第十届全国天然有机化学学术会议 | 被引量 : 0次 | 上传用户:jian85733547
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从银鹊树叶子的内生真菌Penicillium citrinum的液体培养的萃取物中,经过正相色谱、反相色谱、Sephadex LH-20等色谱方法分离得到五个化合物,通过NMR、MS等方法确定该五个化合物结构,其中化合物1和2为新的糖苷类化合物,3-5为已知的蒽醌类化合物.经过体外的细胞毒实验结果显示,化合物1和2对Caski、HepG 2、A549细胞均有不同程度的抑制率,其IC50值分别为12.2、15.6、10.5、13.2、17.6及24.5μg/mL.
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