【摘 要】
：
Gastric cancer is the second leading cause of cancer-related death worldwide.RNA nanotechnology has recently emerged as an important field due to recent findings of its high thermodynamic stability,fa
【机 构】
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National Center for Translational Medicine(Shanghai)Shanghai Engineering Research Center for Intelli
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Gastric cancer is the second leading cause of cancer-related death worldwide.RNA nanotechnology has recently emerged as an important field due to recent findings of its high thermodynamic stability,favorable and distinctive in vivo attributes.Here we reported the use of the thermostable three-way junction(3WJ)of bacteriophage phi29 motor pRNA to escort folic acid,a fluorescent image marker and BRCAA1 siRNA for targeting,imaging,delivery,gene silencing and regression of gastric cancer in animal models.In vitro assay revealed that the RNA nanoparticles specifically bind to gastric cancer cells,and knock-down the BRCAA1 gene.Apoptosis of gastric cancer cells was observed.Animal trials confirmed that these RNA nanoparticles could be used to image gastric cancer in vivo,while showing little accumulation in crucial organs and tissues.The volume of gastric tumors noticeably decreased during the course of treatment.
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