【摘 要】
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A major challenge in cancer therapy is localized targeting of cancer cells for maximum therapeutic effectiveness.However,due to the heterogeneities of cancer biomarkers,the current biomarkers are eith
【机 构】
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The Institute for Biomedical Engineering & Nano Science,Tongji University School of Medicine,No.1239
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
A major challenge in cancer therapy is localized targeting of cancer cells for maximum therapeutic effectiveness.However,due to the heterogeneities of cancer biomarkers,the current biomarkers are either not readily available or specific for effective targeting of cancer cells.The key,therefore,is to develop a new targeting strategy that does not rely on biomarkers.A general hallmark of cancer cells is the much increased level of glycolysis.The loss of the highly mobile lactate from the cytoplasm inevitably removes the labile inorganic cations to form lactate salts and acids as part of the lactate cycle,creating a net negative surface charge.This net negative charge on cancer cell surfaces biophysically distinguishes themselves from the normal cells.In this study,cancer cells are targeted by using posstively-charged,fluorescent,superparamagnetic Fe3O4-nanocomposites.
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