Stilbene compound as a single-stilbene compound body,since the vinyl bond and a benzene ring form a conjugated system alternately,so that it has good chemical properties and widely used in medicine,fo
Multicomponent reactions (MCRs) have emerged as powerful tools to construct diverse functionalized molecules via the formation of multiple bonds in a one-pot operation with high atom efficiency,straig
N-Arylbenzotriazoles are one of the most important classes of N-heterocycles in biological,pharmaceutical and medicinal chemistry.Many these structural motifs possess antiplasmodial,antibacterial,anti
拟三糖allosamidin 1 (Scheme 1)是有效的18家族几丁质酶抑制剂,其具有杀虫和抗真菌活性.但allosamidin类化合物的合成是相当困难的,它是一具有挑战性的课题.分别用固-液相和全固相两种方法合成allosamidin类化合物.固-液相方法实现allosamidin类化合物的部分固相合成；全固相方法大大简化分离纯化的过程.而且,发现易于合成的N,N-二乙酰基-β-几丁二糖a
A series of unsymmetrical pyridine-bridged pincer-type imidazolium salts have been synthesized and demonstrated as highly active catalyst for the cycloaddition of carbon dioxide with a broad range of
九元氮杂环化合物不仅出现在天然与非天然的化合物中,而且也用作合成多种生物碱的有用中间体,而且九元杂环的合成一直也是有机合成领域的一个难点。本课题组一直从事硝酮的合成及其在合成氮杂环骨架中的应用。我们首次以N-烯基-α,β-不饱和硝酮与异氰酸酯为试剂,通过[3+2]环加成反应形成五元氮杂环中间体,进而发生3,3-重排反应,高立体选择性的一锅法构建二氮杂环壬烷骨架。反应底物范围广,官能团的兼容性好,产
Owing to their importance in natural product,biological and pharmaceutical chemistry,various methods have been developed for the synthesis of heteroaryl thioethers,which includes transition metal (TM)
吡咯是许多具有生物活性的天然产物和药物分子的基本骨架[1],是一类重要的杂环化合物.1,3-偶极环加成反应被广泛应用于合成四氢吡咯化合物[2],而利用环加成反应合成吡咯化合物的报道很少,且主要是基于脱除离去基团的芳构化反应[3],仅有少数基于氧化脱氢芳构化反应的报道也具有底物适用范围窄,需要分步反应,氧化剂价格昂贵、毒性大、副产物难以分离等缺点[4].因此,寻找可用于串联反应的、价格低廉、低毒性的