【摘 要】
：
The ATM protein kinase is implicated in the DNA damage response and in sensing DNA double strand breaks.However, recent observations have involved ATM in non-nuclear pathways.ATM belongs to the PIKK f
【机 构】
：
IFOM-FIRC Institute of Molecular Oncology,Milan,Italy
【出 处】
：
The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
The ATM protein kinase is implicated in the DNA damage response and in sensing DNA double strand breaks.However, recent observations have involved ATM in non-nuclear pathways.ATM belongs to the PIKK family, which includes also mTOR, DNA-PK and ATR.Despite their diverse biological roles, these kinases share a similar structure characterized by the presence of a PI3K domain in the C-terminus and an N-terminal portion composed of interspersed HEAT repeat units.We recently showed that ATR mediates a response to mechanical stress by relocating at the nuclear envelope.
其他文献
Structure-specific nucleases play crucial roles in DNA replication and DNA repair.The mechanisms of their regulation are not fully understood.Recently we reported a fission yeast protein, Pxd1, that r
DNA double strand break is one of the most detrimental DNA damages, which must be repaired for the maintenance of genomic stability.Damage recognition by the Mre11-Rad50-Nbs1 complex is the earliest e
DNA double-strand breaks can harbour different types of chemical moieties that differ from the canonical 5phosphate and 3hydroxyl at the ends.Cells are therefore endowed with a wide variety of enzymat
The MRN (Mre11-Rad50-Nbs1) complex is well known for participating in DNA damage response pathways in all phases of cell cycle.Here we show that MRN constitutes a mitosis-specific complex, named mMRN,
The ATR-Chk1 pathway is critical for DNA damage responses and cell cycle progression.Chk 1 inhibition is more deleterious to cycling cells than ATR inhibition,raising questions about ATR and Chk1 func
As replication forks move across chromatin DNA, they frequently stall at hundreds to thousands of intrinsic replication barriers and DNA lesion sties.Stalled forks must require intra-S phase checkpoin
DNA damage response (DDR), an essential singling cascade for genome integrity, must be strictly regulated as either loss of, or augmented DDR leads to unintended consequences of cell fates.Here, we id
The ATR pathway controls chromosome integrity and chromatin dynamics.We recently found that ATR, ATRIP and Chk1 associate to the nuclear envelope during S phase and prophase and in response to mechani
Although we know a great deal about DNA DSB repair pathways in general, very little is known about how DSB repair is affected by its natural context in the cell, that is, within chromatin.Chromatin st
A broad repertoire of modifications is known to underlie adaptable coding and structural function of proteins, DNA and various RNA species.Methylations of mammalian DNA and histone residues are known