• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. A fast analysis of fragmentation pathways of four representative pentacyclic triterpenoids by LC-ESI

A fast analysis of fragmentation pathways of four representative pentacyclic triterpenoids by LC-ESI

来源 :中国药理学会网络药理学专业委员会成立大会暨首届网络药理学学术会议 | 被引量 : 0次 | 上传用户：wcf2009
【摘 要】
：
Aim: The representative pentacyclic triterpenoids including madecassic, asiatic, ursolic and glycyrrhetinic acids, have been found to possess many pharmacological effects.This study is to conduct an a
【作 者】
：
XIA Bin-Bin BAI Lu LI Xiao-Rong XIONG Jie TANG Yu XU Pin-Xiang XUE Ming 
【机 构】
：
Beijing Laboratory for Biomedical Detection Technology and Instrument, Department of Pharmacology, S
【出 处】
：
中国药理学会网络药理学专业委员会成立大会暨首届网络药理学学术会议
【发表日期】
：
2014年3期
【关键词】
：
pentacyclic triterpenoids fragmentation pathways metabolites LC-ESI-MSn 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: The representative pentacyclic triterpenoids including madecassic, asiatic, ursolic and glycyrrhetinic acids, have been found to possess many pharmacological effects.This study is to conduct an analysis of fragmentation pathways of the four representative pentacyclic triterpenoids by LC-ESI-IT-MSn and the application to identify the in vivo conjugated metabolites.
其他文献
Activation of AMPK-TSC axis is involved in cryptotanshinone inhibition of mTOR signaling in cancer c
Cryptotanshinone (CPT), a fat-soluble tanshinone from Salvia miltiorrhiza Bunge, has been demonstrated to inhibit mTOR pathway, resulting in inhibition of cancer cell proliferation.However, the molecu
会议
CryptotanshinoneAMPKTSC2mTORCancer cells
Identification of hub genes related to the hypoxia preconditioning mice by microarray and integrated
Aim: Hypoxia preconditioning is associated with many complicated pathophysiological and biochemical processes that integrated and regulated via gene levels.Up to date, the effect of HPC on global gene
会议
IdentificationHub GenesHypoxia PreconditioningNetwork Analysis
Variation of pathways and networks profiles reveals the differential pharmacological mechanisms of e
Using a systems pharmacology strategy, this study evaluated the unique pharmacological characteristics of three different neuroprotective compounds for the treatment of cerebral ischemia-reperfusion.
会议
Systems pharmacologyBaicalinJasminoidinUrsodeoxycholic acidbrain ischemia
Dissecting the network of drugs and their affected metabolic subpathways
The illustration of the overall drug impact from a "network" view is very important in todays biology and medicine.If a local region of a metabolic pathway (subpathway) contains many drug-affected pro
会议
drugssubpathwaynetwork
Determining Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor by an in silico
Urea transporter B (UT-B) is a membrane protein extensively expressed in various tissues, such as kidney, testis, brain, bone marrow, spleen and erythrocyte, but the specific biological function is we
会议
UT-B inhibitorDiureticsHigh Throughput Virtual Screening (HT-VS)Erythrocyte l
Development and validation of a novel computational approach to identify epigenetic biomarkers assoc
Background: DNA methylation is one of the essential epigenetic mechanisms that are closely correlated to the prognosis progression in human cancer.Advances in computational approaches have generated m
会议
Cancer prognosisDNA methylationSurvival analysis
Stereoselective metabolism of phencynonate isomers and their molecular docking with the mAChR
Aim: To study the stereoselective metabolism of phencynonate isomers and their molecular docking with the mACh receptor.Methods: Phencynonate enantiomers were isocratically separated and determined by
会议
phencynonatechiral metabolismcytochrome P450protein bindingCaco-2 cellsmole
Regulation and new target of G protein-coupled receptors signalling networks in rheumatoid arthritis
Objective: G protein-coupled receptors (GPCRs) signalling networks are involved in many pathophysiological processes including pathways relevant in Rheumatoid arthritis(RA).GPCRs signaling, such as ad
会议
G protein-coupled receptorsrheumatoid arthritisdendritic cellsGRK2CP-25
Liquid chromatography-mass spectrometry based metabonomic investigation into the potential biomarker
Aim: To investigate the metabonomics and potential biomarkers for acute repetitive hypoxia.Methods: The metabonomics methods utilizing LC-MSn and multivariate statistical technique have been successfu
会议
metabonomicsbiomarkersacute repetitive hypoxiamice brainLC-MS
Chemopreventive efficacy of menthol on carcinogen-induced cutaneum carcinoma through inhibition of i
Inflammation and oxidative stress have been implicated in various pathological processes including skin tumorigenesis.Skin cancer is the most common form of cancer responsible for considerable morbidi
会议
Skin tumorigenesisCancer chemopreventionMentholInflammationOxidative stress