Amphiphilic peptide dendritic copolymer-doxorubicin nanoscale conjugate self-assembled to enzyme-res

来源 :中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户:linlin1688
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Chemotherapy has great advantage as one of therapeutic routes for cancer therapy while many antitumor drugs have to face the problems of low antitumor efficiency and rebarbative toxic side effects.To overcome those challenges,some nanoscale drug delivery systems have been designed and employed to enhance their accumulation into tumor via EPR effects.The polymer-drug conjugate therapeutics demonstrated good stability in plasma and serum during transportation and permitted intralysosomal drug release after endocytosis.
其他文献
Ursolic Acid(UA)is natural compound which has been shown to possess wide range of pharmacological activities including anti-inflammatory,anti-cancer,anti-oxidant and anti-microbial effects,but its bio
Circulating tumor cells (CTCs) were considered to be preconditions for the metastasis and recurrence of cancer.We hypothesized that adhesion of CTCs to vascular endothelial bed might be a crucial star
会议
Targeted delivery of therapeutic nanoparticles have shown a significant feature in disease-specific manner compared with non-target nanoparticles.We have developed NPs formulated with poly(D,L-lactic-
Terahertz (THz) wave has numerous applications due to its capabilities of penetrating many materials such as plastic,clothes,woods,ceramic,rubber and so on,and characteristic spectra of chemicals,drug
会议
Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues.According to the World Health Organization,cancer is a leading cause of death and
会议
DNA四面体具有良好的生物相容性与稳定性,能实现结构和尺寸精确可控,在分子影像和分子治疗等领域有了广泛的应用[1,2].同时,DNA四面体作为一种有效运载阿霉素的纳米载体,己经被应用于肿瘤的靶向诊疗的研究中[3].
会议
目的:纳米活性炭(C)可作为胃癌转移的诊断试剂和靶向药物递送系统的载体,但生物安全性是其向临床应用转化过程中的关键间题。本研究以斑马鱼为动物模型,对C的生物安全性进行评估。
Compared to traditional lymph node biopsy,non-invasive imaging techniques for the diagnosis of metastatic lymph nodes are playing a more important role[1].But nonspecific results such as obtained size
会议
In order to explore the size effect of polymeric micelles on cellular internalization and tumor targeting,chrysin modified mPEG-PCL copolymer micelles with different particle sizes were fabricated to
会议
Bioreducible polymers have gained enormous attention in gene delivery due to the high stability in extracellular fluids and rapid DNA unpacking in an intracellular reducing environment,as well as decr
会议