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Objective: To evaluate the outcomes of comprehensive treatments for the extensive venous malformations (VMs) of oral and maxillofacial region.Methods: To review the data of 36 cases with extensive VMs from December 2011 to December 2013.All VMs have involved in at least two anatomical sites and treatment has been completed.Of the 36 cases, 27 underwent embolism and sclerotherapy of fibrin glue (FG) combined with pingyangmycin(PYM), and subsequent injection of PYM only;9 underwent radiofrequency ablation, or surgical resection besides embolism and sclerotherapy of FG combined with PYM.The therapeutic effects were evaluated by clinical examination, ultrasonography with Doppler, or Magnetic resonance imaging (MRI).The follow-up time was from 3 months to 2 years.